Which is the most widely abused drug in the United States and can cause delirium tremens on withdrawal?

• A. Cocaine
• B. Marijuana
• C. Alcohol
• D. Opioids

Answer: (C)

Alcohol is the substance most commonly misused in the United States, due to its wide availability and social acceptability. When someone with long‑standing, heavy drinking suddenly reduces or stops, the brain and body react in a hyperactive way as they readjust to life without alcohol. This withdrawal can progress to delirium tremens, a dangerous state characterized by severe tremors, confusion, agitation, hallucinations, and autonomic instability (rapid heart rate, high blood pressure, fever). Delirium tremens typically appears about 48 to 72 hours after the last drink and requires urgent medical treatment to prevent serious complications or death. Other drugs can cause withdrawal symptoms, but delirium tremens is specifically tied to alcohol withdrawal, and alcohol’s prevalence makes it the best match for the question.